![]() ![]() Bradypnea and pulmonary edema (non-cardiogenic), apnea.Bradycardia, hypotension, arrhythmias, asystole.Tachycardia, palpitations and hypotension.CNS stimulation ( Headache, anxiety, confusion).Inhalation exposure may cause syncope and death after only a few breaths.Inhaled toxins more rapid than ingested.Affected by dose, route, formulation and exposure pattern.They found 50% ROSC in fire victims in full arrest when hydroxycobalamin was administered. Full arrest without full body burns incompatible with life.Paris Fire Brigade protocol recommend hydroxocobalamin administration patients who have had known smoke inhalation in an enclosed space with any of the following: Causes switch from aerobic to anaerobic metabolism despite adequate O2.Binds to cytochrome oxidase in mitochondria leads to cessation of electron transport.Pits of peaches, pears, apricots, crab apples.Gaseous chemical weapon known as prussic acid, hydrogen cyanide, or hydrocyanic acid.Burning of nitrogen-containing polymers (plastics, wool, silk).5.2 Cyanide Antidote Package (Lilly kit). ![]() Cyanide antidotes may also dilate the blood vessels to reduce oxygen demand. Metabolic acidosis (a condition in which there is excess acid in the body fluids)Ĭyanide antidotes usually combine with cyanide to form a less toxic product that can be easily excreted from the body.Hypoxia (a condition where not enough oxygen reaches the cells and tissues in the body).It inhibits oxidative phosphorylation in the cells-a process where oxygen is utilized for energy production-that can cause: Medical exposures such as sodium nitroprussideĬyanide mixes into the bloodstream rapidly.The most common causes of cyanide poisoning are: Cyanide antidotes are drugs used for treating cyanide poisoning. ![]()
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